Chronic HBV infections are widespread, affecting 296 million people worldwide and resulting in more than 800,000 deaths each year.

While research is ongoing, generating high-quality, pre-clinical data that translates well to the human environment is challenging, and conventional models can result in misleading metabolism, pharmacokinetics, efficacy and hepatotoxicity information.

In this case study, we discuss how PXB-mice with humanized livers are helping researchers investigate the entire HBV lifecycle, resulting in translationally relevant data for pre-clinical research.

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